I've shot alot of PD's,rattlesnakes,jackrabbits,starlings a porcupine or two with those bullets.They make the segmented bullets for the .22Mag also but I have'nt tryed those out yet.I agree though,they will end a prairie dogs career in short order.I had a little trouble with a porcupine I shot with them though.My first shot hit it right square in the teeth and of course it blew its teeth out.It also took its nose and bottom jaw off but the porcupine was still alive for about 5 seconds.They break apart really easily so if it hits bone on a heavier bodied animal your gonna do alot of damage but the bullet wont penetrate very well.My uncle shot a jackrabbit with a Quickshock and it litterally looked like it had been hit with a centerfire rifle.He shot it in the chest if I remember right and the bullet came out of its stomach.I did'nt flip it over to see how big the hole was but I can tell you by the pile of stuff that jackalope was layin in that it was probably a biggun'.As much as I like the Quickshocks or Segmented Bullets I still keep shootin the Federal HP's in the bulk pack.Wal-Mart does'nt carry Quickshocks and thats about the only reason for that.