Every time you get a different lot# of powder from any manufacturer, you need to re-verify your load.
For example, N-133 is supposed to be top drawer in quality. I worked up a load for my 223 AI with it, bought another two pound bottle, and load was so hot with the second bottle, I pierced the primer and ruined my two oz trigger.
My friend in Salt Lake shoots the 55's in his 6 BR with 35.0g of AA2230 and I shoot 34.0...different lots, differnt barrels, etc.
I have also worked up loads with the 65 and 70-75g Bullets with it also with excellent accuracy.
As far as temp sensitivity, you will have to use your best judgment for your area and find out for yourself.
I can tell you that the speeds with this powder with all bullets are way above H322 and Benchmark.
When I was shooting benchrest matches, we loaded at the range so that we could load more powder in the cold mornings and less in the heat of the day. N-133, Norma 201, H322 dominate matches with the 6PPC, and those powders are among the best in being "temp sensitive".