Good question..
NORMALLY, the higher impact velocity will have a more violent upset and less penetration than the lower velocity especially on the TNT bullet. Keep in mind though that any larger fragments will also have more penetration potential at the higher velocity. That being said the TNT, according to Speer, is designed for total disruption upon impact.
I just looked at an open box of 6mm 70g TNT. There are no warnings on the outside of the box, but on the inside was an insert saying "not recommended for rifles having twists quicker than 1 turn in 9 inches". "Do not exceed velocities of 3,550 feet per second".
Hope this helps. Good Luck!