It could be made but there could be some feeding problems with the magazines. The 22-250 is simply too long for an AR15 so your talking one of the 308 platforms from either armalite or DPMS. The 308 case wall is longer and has much less taper that the 22-250. The fact that the taper is greater with the 22-250 may require the magazine lips to be modified. The good thing is the 22-250's base is exactly the same so no modification of the bolt would be needed. With the 22-250 being smaller all the way around, you might try to see if it would feed into a 308 AR-10. I would use cases with just the bullets properly seated with no powder or primers installed. If they would hand cycle thru the gun you probably won't have feeding problems. WARNING: AR10 parts are expensive. I'm having a custom upper made in 243 and it will probably end up costing me $1,600 bucks when done. This upper will have a shilen barrel so the quality will be better than a factory gun. I was just ordering my last part from armalite when told by the customer service person that they were going to start making the 243 again. You might call them to see if they are going to make the 250 again.