I don't shoot over 50 coyotes a year either but I've shot a lot more than 50 coyotes in my life.
I assume you're looking for a "fur load" but you didn't specify. For fur, as you probably already know, you'll always walk a fine line between exits and splashes. Too light= splash; too heavy= exits if all other things are equal (which they rarely are). If you use the v-max, go heavy. The lighter bullets will poleaxe coyotes with the right shots and the right velocities but you will also lose some when things don't line up. The 60 grain v-max works best for us at moderate .22-250 velocities. I've had terrible luck with hollow points in the .22-250. Berger, Speer, Sierra, and Hornady hollow points all tear them up. Remington PSP will exit on rib shots but not with huge holes in my experience. Forty grain bullets at hot .22-250 velocities will splash on quartering-on shoulder shots.
The Berger .204 35 grain hp has accounted for the most coyotes and cats with little pelt damage and very few, if any, splashes. We shoot them at all angles and distances as the shots present themselves. The 32 gr poly-tipped .204 bullets, however, will have the same problems as the 40 gr .22-250 bullets.
Good luck.