I have been shooting the 280AI know for about 5 years. You will love it.
After several years of downing a few coyotes in the 400-500 yard range with a custom .243 I was wanting a deer rifle that would give me that kind of range. I did a lot of reading, research, and talking to some of the best in the industry. Several of Steve Timms' articles (Varmint Hunters Magizine) and then finally Kenny Jarrett sold me on the 280AI. Although I really wanted a Jarrett rifle, I just could not afford his quality. I talked with Hart, Lilja, Kreiger, McGowen, Carolina Precision, and Pac-Nor about fitting and rebarreling a Remington 700 action. I ended up with Pac-Nor and have not been disappointed. I pillar bedded, free floated, and glassed the wood stock myself. It shoots great and would be any deer hunters dream.
Mine is and I would recommend a 1:10 twist for this caliber with a good 140 grain bullet for deer sized game. I say good bullet because I had problems with the 140 Nolser BT coming apart on shots inside 150 yards (about 3,200 FPS). The Sierra 140 SBT, and the Barnes 140 TS both shoot 1/2 MOA or better and stay together. The Barnes is the best. The 1:10 twist will also work well with 160 grain bullets but I think that is a little much for deer unless you are fortunate enough to tangle with some of the 250 lb plus monsters. Even then the 140 Barnes TS is easily up to that task. I did get to go on one Elk hunt and used the 160 grain TS. Went through both shoulders at about 125 yards. He only went a couple of feet... straight down.
Some will try to talk you into a faster twist but you just don't need it unless you are planning on shooting over 160 grain bullets. I think most of the factory "experts" I mentioned earlier would tell you that If you are going to shoot over 160 grain pills you should be shooting a 30 caliber.
Have a good smith tune your factory trigger or get a Timney. Depending on your barrel contour the HS Precision is about as good as any if you are not going to bed the factory stock.
After you get your AI send me a PM and I will send you my loading info. WELCOME to the Ackley crowd.
GOOD LUCK !!